Genetic Sequencing Unit
Add-on for ASBL machines like GPU (Graphics Processing Unit) for PC (personal computer)
Microfluidic unit sequences DNA post PCR. Flow cell size. GSU is being designed to be reprogrammable for all applications listed below to probe diverse biology.
Application (reference): biology probed
DNAseq (whole genome sequencing): genome
WES (whole exome sequencing): protein-coding genes (exons)
RNAseq (bulk RNA sequencing): active mRNA across bulk tissue (many cells), transcriptome
scRNAseq (single-cell RNA sequencing): active mRNA in single cells, active genes, single-cell transcriptome
ATACseq: chromatin accessibility, epigenome
Hi-C: chromatin position, long-range contact like genes and regulatory elements, transcription regulation
EM-Seq (Enzymatic methyl-seq): DNA methylation
ChIPseq (chromatin immunoprecipitation massively parallel sequencing): binding sites of proteins on DNA
16S rRNAseq (16S ribosomal RNA sequencing): bacterial identification
ITS-seq (Internal Transcribed Spacer sequencing): fungal and bacterial identification
Bioengineers can add sequencing applications like CITE-seq and SMART-seq by reprogramming GSU using ASBL Machine Protocol