Organoid chips
An organoid (1,2) is a small clump of living cells. It survives independently if provided with nutrients and waste clearance. US FDA is replacing animal trials for drugs, starting with monoclonal antibodies, with organoids and organ-on-a-chip systems.
ASBL machines use organoids. ASBL machines have in-built functions (in ASBL machine protocol) to provide nutrients to and extract waste from organoid microenvironments. An ASBL organoid chip is called a biofloppy, and is used like a floppy disk.
Biofloppy Usage
1. Insert a biofloppy with organoids in the biofloppy drive of an ASBL machine
2. ASBL recognizes the biofloppy and displays media requirements
3. Insert a 96-well plate with required media into the ASBL machine for organoid maintenance
4. Access biofloppy applications with ASBL terminal
Biofloppy Applications
1. Create patient organoids from autologous (derived from patient) cells
2. Test personalized therapies on patient organoids in cancer and autoimmune diseases
3. Develop organ-targeting and cell-targeting therapies with parallel assays on multiple biofloppies
4. Cell therapy research and manufacturing
Available Biofloppies (order by email)
1. Bone marrow biofloppy
2. Cardiac muscle biofloppy
3. Liver hepatocyte biofloppy
4. Lung biofloppy
5. Neuron biofloppy
6. Intestinal biofloppy
7. Endometrium biofloppy
8. Skin epithelium biofloppy
9. Empty biofloppy (create and save organoids)
Deconstructed Human is a package sold commercially by ASBL. It includes one of all available biofloppies, 96-well plates with 90-day media for all biofloppies, and training on organoid manipulation on ASBL machines.